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KMID : 0379520100260020117
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한국독성학회지
2010 Volume.26 No. 2 p.117 ~ p.121
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Antifungal Effect of Brachyglottis repanda Ethanol Extract
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Yook Chan-Nam
Na Young-Soon
Choi Hwa-Jung
You Il-Soo
Baek Jong-Min
Baek Seung-Hwa
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Abstract
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The crude ethanol extract of B. repanda showed the cytotoxic activity against Polio virus (25% activity at 150 ㎍/disk) and the minor cytotoxic activity against BSC cells (African green monkey kidney). However, the crude ethanol extract of B. repanda was non-toxic to murine leukaemia cells CCL 46 P388D1 (IC??, ＞ 62,500 ng/ml). Cytotoxic and antifungal activities were strongly shown by Fr. 64-3 which was eluted with 90% CH₃CN/H₂O, 100% CH₃CN, and 50% CH₃CN/H₂O (SM 2 at 150 ㎍/disk). The fraction 64-3 also showed the most cytotoxic activity against murine leukaemia cells (128 ㎎, IC?? 10,051 ng/ml at 75 ㎍/disk). These results suggest that this fraction has a potent antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185.
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KEYWORD
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Brachyglottis repanda, Cytotoxic activity, Murine leukaemia cell lines, Trichophyton mentagrophytes, Antifungal activity, Antiviral activity
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